NoPain

Vitobest®, in its eagerness to improve the unimprovable, has reformulated its star pre-workout, NoPain.

More muscle congestion, more strength, more endurance, and more focus to push your workouts to the limit.

From Vitobest® we know that in order to overcome our limits and push our workouts to the extreme, we must act on all the pathways that influence better sports performance:

• Strength: Increasing the capacity of our muscles to obtain more energy in less time and enhancing the recruitment of muscle fibers by our nervous system.
• Resistance: Replenishing the ions that are lost during training and reducing muscle fatigue, maintaining pH balance and reducing the perception of fatigue at the brain level.
• Anabolism: providing all the available nutrients and oxygen to our muscle fibers to enhance their performance and optimize our own hormonal production.
• Cognitive focus: stimulating the nervous system to maintain explosiveness and increase intensity for a longer time.

NoPain, from Vitobest®, combines the most potent active ingredients along with high doses of caffeine and amino acids that act on these pathways, in addition to being reinforced with minerals to leave nothing to chance:

• β-Alanine (CarnoSyn®): Non-proteinogenic amino acid precursor of carnosine, whose function is to maintain the acid-base balance in skeletal muscles, the brain, and the heart. Thanks to this buffering, β-Alanine can reduce acidosis without influencing oxygen consumption^1,2. β-Alanine also acts at the neuronal level, reducing the perception of fatigue during exercise³. These effects at the muscular and nervous system level promote improvements in performance and athletic explosivity. In addition, numerous studies have confirmed the synergistic effect on athletic performance when combined with creatine⁴.
  
  
• Clonapure® Creatine: Creatine in its active form, phosphocreatine, is much more effective and provides immediate energy. Creatine mainly acts through its effects on energy metabolism, regenerating cellular ATP⁵. In this way, it improves strength and power during endurance exercise, as well as increases lean mass⁶. Numerous studies in athletes confirm their ability to reduce body fat and improve anaerobic exercise performance, strength, and power output⁷. It also reduces mental fatigue in times of sleep deprivation or exercise to exhaustion⁸.
  

   

  

   

• L-Arginine and L-Citrulline: amino acids directly related to the increase of nitric oxide in blood (NO). NO is a key molecule that promotes vasodilation and, therefore, the arrival of nutrients, oxygen, and hormones to both the muscle and the central nervous system more easily, achieving a reduction in perceived effort, decrease in muscle pain, and increase in power^9,10,11. NO could also have direct effects on the contractile function of the muscle¹². In addition, they are intermediaries in the urea cycle, responsible for the excretion of ammonia, whose accumulation leads to muscle fatigue during exercise and reabsorption of bicarbonate, reducing acidity^13,14. At a hormonal level, L-Arginine can promote anabolism by promoting the secretion of growth hormone¹⁵.
  
  
• L-Taurine: L-Taurine is a sulfuric amino acid abundant in tissues such as the heart, brain, and skeletal muscle. Taurine is considered a conditionally essential nutrient, meaning that we can produce it in our body, but under demanding conditions we may not produce enough to meet all our needs¹⁶. It improves vasodilation, relaxing the vessels, in addition to reducing blood pressure by decreasing the production of angiotensin II, a potent vasoconstrictor^17,18. Taurine can improve physical performance by increasing the calcium storage capacity of the sarcoplasmic reticulum, as well as the sensitivity of actin and myosin (force-generating proteins) to calcium, thus increasing muscle strength¹⁹. Similarly, it can help performance, increase the use of fat as fuel, in addition to improving mitochondrial function²⁰.
  
  
• L-Tyrosine: L-Tyrosine is a key amino acid in the production of catecholamines, dopamine and norepinephrine, and thyroid hormones, which can be depleted under physical and mental stress conditions. These hormones have a direct implication with the maintenance of cognitive focus, motivation and reduction of the perception of exhaustion. L-Tyrosine has the ability to replenish catecholamine levels in the brain and prevent their decrease, which can be depleted in intense and strenuous workouts^21,22.
  

   

  

   

• Dry extract of Rhodiola rosea: The Rhodiola rosea It is an adaptogen that acts at the brain level providing positive effects on sports performance. Studies confirm that it increases strength and power when taken just before training, in addition to reducing the rate of perceived exertion^23,24,25. On the other hand, it improves blood flow by acting to inhibit the ACE enzyme at the kidney level, which promotes vasoconstriction²⁶.
  
  
• Sodium citrate, potassium citrate, and calcium bisglycinate: Ions are essential for a wide variety of metabolic processes in our bodies. High-intensity or prolonged workouts can lead to their loss, causing temporary deficiencies that directly affect the proper functioning of our muscles and nervous system, negatively impacting our physical and mental state. Therefore, correctly replenishing these ions is key to reducing our sensation of fatigue and maintaining our performance.
  
  
• Oxystorm®: patented extract of red spinachAmaranthus hypochondriacus) that provides a high concentration of nitrates. Oxystorm® It is capable of increasing the levels of nitrates and nitrites in both saliva and plasma, these being precursors of NO, promoting blood flow and athletic performance²⁷.
  

   

  

   

• AshwaNature Root®: Adaptogen with multiple therapeutic uses, where its actions at the level of the nervous, hormonal and metabolic systems provide broad benefits in terms of sports performance^28,29,30,31.
  
  > It reduces the perception of pain and fatigue by stimulating endogenous opioid receptors.
  > Increase theMax VO₂, the strength and muscle size. Moreover, it reduces body fat and increases testosterone levels.
  > Reduces systemic inflammation, oxidative stress and blood lipid levels by regulating insulin levels.
  

   

  

   

• Natural Caffeine, Coffit Nature®: Formulated with a dose of 400 mg to produce a more potent effect on the central nervous system, muscle, and adipose tissue. It stimulates the secretion of excitatory neurotransmitters such as dopamine or noradrenaline thanks to its action on two pathways; inhibiting the action of adenosine and the enzyme PDE (cyclic nucleotide phosphodiesterase)^32,33,34. It promotes the release of fatty acids to be used as an energy source through mitochondrial oxidation in cells, reducing the percentage of body fat. It increases the intracellular transport of calcium during muscle contraction, directly improving the contraction capacity, the number of muscle fibers recruited, and therefore, muscle strength and hypertrophy^35,36,37.
  

   

  

   

• AstraGin®: This ingredient based on extracts ofPanax notoginsengAndAstragalus membranaceusImproves absorption at the intestinal level, optimizing the effect of the rest of the product's components.

NoPain features:

NoPain, from Vitobest®, it's the definitive Pre Workout, where more strength, more congestion, more energy, and more resistance are combined with inexhaustible power.

Bibliography:

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²Artioli GG, Gualano B, Smith A, Stout J, Lancha AH Jr. Role of beta-alanine supplementation on muscle carnosine and exercise performance. Med Sci Sports Exerc. (June 2010)

³Stout JR, Cramer JT, Zoeller RF, Torok D, Costa P, Hoffman JR, Harris RC, O'Kroy J. Effects of beta-alanine supplementation on the onset of neuromuscular fatigue and ventilatory threshold in women. Amino Acids. (2007)

⁴Zoeller RF, Stout JR, O'kroy JA, Torok DJ, Mielke M. Effects of 28 days of beta-alanine and creatine monohydrate supplementation on aerobic power, ventilatory and lactate thresholds, and time to exhaustion. Amino Acids. (September 2007)

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