Pain Gel

Pain Gel, from Vitobest®, is a gel made from extracts and oils that are 100% natural and of the highest quality. Its active ingredients penetrate the skin and help to relieve pain, reduce inflammation, and speed up recovery.

The combined action of the ingredients Pain Gel It allows for effective intervention in all treatment phases: it contributes to the recovery of muscular, tendinous, and joint injuries, as well as to alleviate daily discomfort and pain.

How is it different from other products?

Contrary to other products, whose ingredients focus on stimulating the skin's nerves to provide a feeling of cold or heat; the effectiveness of Pain Gel, from Vitobest®, it is based on:

• Effective and comprehensive control of the most important mediators of inflammation (cyclooxygenases, lipogenesis, and il6- Il1-il 10)^1,3,4,7,10.
• Pain reduction¹.
• Faster reabsorption of edemas and hematomas, speeding up recovery^5.8.
• Recovery of damaged tissues^6,10.

The reduction of pain and inflammatory processes are two important components in the recovery process from an injury or trauma, as they speed up the generation and recovery of tissues. Hence the meticulous selection of active ingredients. Pain Gel from Vitobest®:

• Harpagophytum procumbens: powerful anti-inflammatory and analgesic action (IL-6, IL-1 inhibitor)¹.
• Calendula officinalis: Anti-inflammatory and anti-edema action. Its calendulosides B and calenduloglycosides have soothing and anti-inflammatory properties². The combination of both significantly increases the levels of pro-inflammatory cytokines (such as IL-1, IL-6)³.
• Boswellia serrata: it contains beneficial compounds known as boswellic acids (BA) that help fight inflammation and reduce oxidative stress⁴.
• Arnica montana (flower extract): It has an analgesic effect on pain caused by inflammation, and the ability to accelerate the reabsorption of bruises^5,8. It also helps to stimulate blood circulation in the area where it is applied.
• Chamomile recutita: Recent studies have shown that it has anti-inflammatory properties that penetrate deep into the skin layers⁶.
• Tea tree (Melaleuca alternifolia): helps to inhibit the mediators of interleukin-1β (IL-1β), and IL-10 and prostaglandin E2⁷.
• Cyperus esculentus (root oil): Its content in alpha-cyperone helps to inhibit the action of hormones responsible for inflammation (prostaglandins)⁹.
• Rosmarinus officinalis: The rosmarinic acid in its composition helps to inhibit inflammatory reactions.¹⁰.

The formula of Pain Gel Vitobest® contributes to:

• Relieve daily discomforts and pains (analgesic effect).
• Reduce inflammation and bruising (powerful anti-inflammatory).
• Recover muscles, joints and tendons.
• Relieve mild localized pain and inflammation.
• Reduce muscle and joint pain.
• Recover from sports injuries.
• Reduce post-exercise pain.
• Relieve lumbar and cervical discomfort.
• Recovering from tendon injuries (tennis elbow, rotator cuff, etc.).
• Reduce the effects of bruises, blows, strains, and minor sprains caused by twists.
• Complement massages, physiotherapy and manual techniques.

Not tested in animals, free of parabens, active ingredients of 100% natural origin and without allergens.

Bibliography:

¹"Clac Currencies"Clac procumbens) in herb with therapeutic potential". McGregor, G. et al.

²"New triterpenic esters of the oleanene series from the flowers of" Calendula officinalis"2005. Linn Naved, T. et al. Indian Journal of Chemistry. 44. 1088-1091. 10.1002/chin.200539165.

³Calendula officinalis - "an important medicinal plant with potential biological properties". Nelofer, J. et al. Plant Molecular Biology Lab., Department of Botany, University of Kashmir, India.

⁴Boswellia serrata "Extract attenuates inflammatory mediators and oxidative stress in collagen-induced arthritis". 2014. Umar, S. et al. Phytomedicine. 21(6), 847-856.

⁵"Studies on the anti-inflammatory activity of phytopharmaceuticals prepared from Arnica flowers". Klaas, C.A. and others

⁶"Chamomile: a herbal medicine of the past with a bright future". Janmejai K, S. et al., Department of Urology & Nutrition, Case Western Reserve University, Cleveland, Ohio.

⁷"Potential anti-inflammatory effects of Melaleuca alternifolia". Caldefie-Chézet, F. et al.

⁸"Screening for anti-inflammatory activity of 12 Arnica species"Asteraceae) species assessed by inhibition of NF-kappaB and release of human neutrophil elastase". Ekenäs, C. et al.

⁹"Medicinal uses and Pharmacological activities of" Cyperus. Linn, A. Review Sri Ranjani Sivapalan.

¹⁰"An in-depth review on the medicinal flora" Rosmarinus officinalis (lamiaceae)"Begum, A. et al. Department of Pharmacology, Vatsalya College of Pharmacy Bhongir, Nalgonda, India."