NADH+D-Ribose

A new approach in cellular supplementation!

Health, performance, and longevity largely depend on the state of cellular metabolism. That's why, Vitobest® has decided to bet on a new generation of supplements that they act directly on the main source of energy of the organism: the mitochondria. Its goal is clear: improve the quality of life, optimize physical and intellectual performance, and support healthy and active aging.

NADH+D-Ribose is part of this vision. A formula that supports energy production from the very core of the cell itself and designed for those seeking to maintain high daily performance and combat fatigue from its mitochondrial origin.

The mitochondria: the cellular engine of your energy and long life.

The mitochondria They are intracellular structures that act as power plants, transforming nutrients into ATP (adenosine triphosphate), the main source of cellular energy¹. Its proper functioning is essential for maintaining physical vitality, mental clarity, recovery capacity, and longevity.².

However, multiple factors of modern lifestyle negatively affect mitochondrial function:

• Diets low in essential micronutrients³.
• Excess of sugars, trans fats and environmental toxins⁴.
• Sedentarism or overtraining⁵.
• Chronic stress, lack of sleep and anxiety⁶.
• Disruption of circadian rhythms⁷.
• Accumulation of free radicals and oxidative stress⁸.

The result is a lower energy production, chronic low-grade inflammation, and accelerated aging.⁹. Supporting mitochondrial health has become a priority to improve performance and quality of life.

ATP: the energy currency of the body.

ATP is the molecule that fuels all the functions of the body: It allows muscle contraction, brain activity, cell regeneration, and protein synthesis.¹⁰.

When it is not produced in sufficient quantity, symptoms such as: appear.

• Persistent fatigue.
• Lack of concentration.
• Low physical and mental performance.
• Slow recovery.
• Muscle aches and feeling of "brain fog."

Therefore, promoting the production and regeneration of ATP becomes a key strategy to combat fatigue and maintain an efficient metabolism.

Intelligent Synergy: NADH+D-Ribose.

The mitochondrial respiratory chain is the system that cells use to produce energy in the form of ATP, which is the "fuel" they use to function. In this process, the NADH (ß-Nicotinamide adenine dinucleotide reduced) performs an essential function: it transports energy in the form of electrons and delivers them to the mitochondria, where they are transformed into useful energy for the body.

When the NADH When the job is done correctly, an internal impulse is generated that activates an enzyme called ATP synthase, responsible for producing ATP. If there is little NADH, this energy chain slows down, and as a result, the cell produces less energy. That's why supplementing with NADH It may be useful in people who suffer from persistent fatigue, concentration problems, or lack of cellular energy, as it helps to restore that natural energy flow.^10,11,12.

On their part, the D-Ribose it is a structural (non-energy) sugar that participates in the synthesis of nucleotides like ATP, NADH, RNA and DNA. When ATP reserves are depleted (whether due to intense exercise, illness, or aging), the body needs to rebuild them from scratch, and ribose accelerates this process.^13,14.

The combination of NADH+D-Ribose allows:

• Activate the respiratory chain to produce energy immediately.
• Provide the necessary precursors for ATP regeneration.
• Improve mitochondrial efficiency and accelerate cell recovery.
• Stabilize the redox balance and reduce oxidative stress¹⁵.

Main benefits of NADH+D-RiboseYou need to provide the text you want to be translated.

• Increases cell energy production (ATP), combating physical and mental fatigue.^1,3.
• Improves concentration and cognitive performance, especially under stress^2.5.
• Promotes muscle recovery after intense workouts or sustained effort^4.6.
• Supports cardiovascular function in people with myocardial weakness or heart failure^3.7.
• Reduces chronic fatigue and improves quality of life in cases of fibromyalgia or burnout.^6.8.

Who is it for?

Ideal for people who experience:

• Chronic fatigue that does not improve with rest.
• Difficulty concentrating or maintaining cognitive focus.
• Slow recovery after physical effort.
• High workload or prolonged stress situations.
• Age-related changes or mitochondrial dysfunction.

NADH+D-Ribose, of Vitobest®, it is the advanced mitochondrial combination that offers you an effective, safe solution, backed by science.

Activate your cell, activate your life with NADH+D-Ribose, from VitobestThe input provided is not in Spanish, it's just a symbol.

Vitobest® used for this supplement vegetable capsules (VegeCaps) suitable for vegan diets and free of titanium dioxide.

Bibliography:

¹Nunnari J, Suomalainen A. Mitochondria: In sickness and in health. Cell. 2012;148(6):1145–1159.

²Wallace DC. Mitochondrial Genetic Medicine. Nature Genetics. 2018;50(12):1642–1649.

³Ames BN. Low intake of micronutrients may speed up the degenerative diseases of aging through the distribution of scarce micronutrients by triage.. PNAS. 2006;103(47):17589-17594.

⁴Sanderson SM, Gao X, Dai Z, Locasale JW. (Note: This is a list of names and doesn't require translation.). Dietary metabolism, the microbiome, and metabolite signaling in cancer. Nat Rev Mol Cell Biol. 2020;21(10):585–602.

⁵Radak Z, Chung HY, Goto S. Exercise, Oxidative Stress and Hormesis. Ageing Res Rev. 2008;7(1):34–42.

⁶McEwen BS. Protective and damaging effects of stress mediators: central role of the brain. Ann N Y Acad Sci. 1998;840:33–44.

⁷Panda S. Circadian physiology of metabolism. Science. 2016;354(6315):1008–1015.

⁸Harman D. Free Radical Theory of Aging: An Update. Ann N Y Acad Sci. 2006;1067:10–21.

⁹Picard M, Wallace DC, Burelle Y. The mitochondrial basis of aging and age-related diseases. Curr Biol. 2016;26(21):R832–R843.

¹⁰Nicholls DG, Ferguson SJ. Bioenergetics 4. Academic Press; 2013.

¹¹Forsyth LM, et al. Therapeutic effects of oral NADH on the symptoms of chronic fatigue syndrome. Ann Allergy Asthma Immunol. 1999;82(2):185–191.

¹²Rex A, Fink H. Effects of NADH on memory and attention in rats. Neurosci Biobehav Rev. 2000;24(1):13–24.

¹³Teitelbaum JE, et al. The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study. J Altern Complement Med. 2006;12(9):857–862.

¹⁴Omran H, et al. D-ribose improves diastolic function and quality of life in patients with congestive heart failure. Eur J Heart Fail. 2003;5(5):615–619.

¹⁵Hellsten Y, et al. Effect of ribose supplementation on the resynthesis of adenine nucleotides after intense intermittent training. Eur J Appl Physiol. 2004;91(5–6):657–662.