PMS Forte

PMS Forte it is a formula by Vitobest® designed for women who, in the days before menstruation, they experience discomfort such as irritability, breast pain, swelling, fatigue or cravings. These symptoms, known as premenstrual syndrome (PMS), affect up to 80% of women of childbearing age.^1,2.

Although we usually associate it only with hormones, PMS is also related to imbalances in neurotransmitters such as serotonin (key for mood) and GABA (relaxation).^3,4, with changes in the levels of estrogen and progesterone^5,6, and with inflammation or oxidative stress processes that worsen the symptoms^7,8.

PMS Forte, by Vitobest®, helps regulate all these factors naturally, thanks to a combination of plant extracts and minerals with scientific backing, designed to balance your hormones, reduce inflammation and help you feel calmer and more fit during this phase of the cycle.

Main mechanisms of action:

1. Hormonal balance and support to the progesterone-GABA axis.

• Vitex agnus-castusYou didn't provide any text to translate. Could you please provide the text you want to translate from Spanish to English? helps regulate the production of progesterone and stabilizes mood¹².
• Magnesium Bisglycinate (Albion™): It favors the activity of the GABA system, improves rest, and reduces physical and emotional tension.¹¹.

2. Serotonin modulation and mood improvement.

• Saffron extract (standardized in crocins and safranal): has been shown to increase brain serotonin and improve symptoms such as anxiety, sadness, or insomnia.¹³.

3. Reduction of inflammation and oxidative stress.

• Turmeric RHIZOmin 95® (95% curcuminoids): It modulates inflammation, regulates aromatase, and contributes to hormonal balance.¹⁴.
• Boswellia AKBAzyme® (30% AKBA): With the highest concentration on the market in AKBA, it inhibits the leukotriene pathway and improves menstrual pain, breast congestion, and pelvic discomfort.¹⁵.

4. Reduction of fluid retention.

• Extract from Corn (10:1): Mild diuretic action, useful for reducing abdominal swelling and premenstrual heaviness feeling.¹⁶.

Vitobest® used for this supplement vegetable capsules (VegeCaps) suitable for vegan diets and free of titanium dioxide.

Product Claims:

• Vitamin B6 helps regulate hormonal activity.

Bibliography:

¹Halbreich U, Borenstein J, Pearlstein T, Kahn LS. The prevalence, impairment, impact, and burden of premenstrual dysphoric disorder (PMDD). Psychoneuroendocrinology. 2003;28(Suppl 3):1–23.

²Rapkin AJ. A review of treatment for premenstrual syndrome & premenstrual dysphoric disorder. Psychoneuroendocrinology. 2003;28(Suppl 3):39–53.

³Del Río P. Serotonin, menstrual cycle and premenstrual syndrome. Dialnet. University of Murcia, 2013.

⁴Sundstrom-Poromaa I, Gingnell M. Influence of the menstrual cycle on cognitive function and emotion processing - from a reproductive perspective. Front Neurosci. 2014;8:380.

⁵Bertone-Johnson ER. Premenstrual Syndrome and Premenstrual Dysphoric Disorder: A Review of the Evidence and Implications for Clinical Practice. Current Psychiatry Report. 2013;15(11):1–9.

⁶Andreen L, Backstrom T. The role of GABA-A receptors in premenstrual dysphoria. Psychoneuroendocrinology. 2009;34(8):1121–32.

⁷Parry BL. Neurotransmitter and hormonal interactions in PMS and PMDD. J Affect Disord. 2001;62(1-2):67–76.

⁸Bertone-Johnson ER, Ronnenberg AG, Houghton SC. Inflammation and oxidative stress in the etiology of premenstrual syndrome. J Women's Health. 2014;23(9):749–57.

⁹Neuman H, Debelius JW, Knight R, Koren O. Microbial endocrinology: the interplay between the microbiota and the endocrine system. FEMS Microbiology Reviews. 2015;39(4):509–21.

¹⁰Heindel JJ, Newbold RR, Bucher JR, et al. Endocrine disruptors and the obesity epidemic. Toxicol Sci. 2015;145(1):61-9.

¹¹Fathizadeh N, Valiani M. Effect of magnesium and magnesium plus vitamin B6 on the severity of premenstrual syndrome. Iran Journal of Nursing Midwifery Research. 2010;15(Suppl 1):401–5.

¹²Loch EG, Selle H, Hoerr R. Treatment of premenstrual syndrome with Vitex agnus-castus. J Women's Health Gender Based Med. 2000;9(3):315-20.

¹³Agha-Hosseini M, Kashani L, Aleyasin A, et al. Saffron in the treatment of premenstrual syndrome: a double-blind, placebo-controlled trial. BJOG. 2008;115(4):515-9.

¹⁴Chainani-Wu N. Safety and anti-inflammatory activity of curcumin. J Altern Complement Med. 2003;9(1):161-8.

¹⁵Ammar A, Turki M, Hammouda O, et al. Effects of Boswellia serrata supplementation on inflammatory response. J Int Soc Sports Nutr. 2017;14:20.

¹⁶Cano A, Villar A. Study of Zea mays L. stigmas: diuretic activity and flavonoid composition. Med Plant. 1982;45(2):84–6.