Pre Training

Vitobest® presents Pre Training, a combination of several active ingredients to push your workouts to the limit.

The new Pre Training it does not contain added carbohydrates or caffeine in its formula, so that the athlete themselves can choose whether to include them according to their needs, objectives, and type of training, because not all athletes or sports disciplines are the same.

From Vitobest® we know that in order to overcome our limits and push our workouts to the extreme, we must act on all the pathways that influence better sports performance:

• Strength: Increasing the capacity of our muscles to obtain more energy in less time and enhancing the recruitment of muscle fibers by our nervous system.
• Resistance: Replenishing the ions that are lost during training and reducing muscle fatigue, maintaining pH balance and reducing the perception of fatigue at the brain level.
• Anabolism: providing all the available nutrients and oxygen to our muscle fibers to enhance their performance and optimize our own hormonal production.
• Cognitive focus: stimulating the nervous system to maintain explosiveness and increase intensity for a longer time.

Pre Training from Vitobest® includes:

• β-Alanine (CarnoSyn®): Non-proteinogenic amino acid precursor of carnosine, whose function is to maintain the acid-base balance in skeletal muscles, the brain, and the heart. Thanks to this buffering, β-Alanine can reduce acidosis without influencing oxygen consumption^1,2. β-Alanine also acts at the neuronal level, reducing the perception of fatigue during exercise³. These effects at the muscular and nervous system level promote improvements in performance and athletic explosivity. In addition, numerous studies have confirmed the synergistic effect on athletic performance when combined with creatine⁴.
  
  
• Clonapure® Creatine: Creatine in its active form, phosphocreatine, is much more effective and provides immediate energy. Creatine mainly acts through its effects on energy metabolism, regenerating cellular ATP⁵. In this way, it improves strength and power during endurance exercise, as well as increases lean mass⁶. Numerous studies in athletes confirm their ability to reduce body fat and improve anaerobic exercise performance, strength, and power output⁷. It also reduces mental fatigue in times of sleep deprivation or exercise to exhaustion⁸.
  

   

  

   

• L-Arginine and L-Citrulline: amino acids directly related to the increase of nitric oxide in blood (NO). NO is a key molecule that promotes vasodilation and, therefore, the arrival of nutrients, oxygen, and hormones to both the muscle and the central nervous system more easily, achieving a reduction in perceived effort, decrease in muscle pain, and increase in power^9,10,11. NO could also have direct effects on the contractile function of the muscle¹². In addition, they are intermediaries in the urea cycle, responsible for the excretion of ammonia, whose accumulation leads to muscle fatigue during exercise and reabsorption of bicarbonate, reducing acidity^13,14. At a hormonal level, L-Arginine can promote anabolism by promoting the secretion of growth hormone¹⁵.
  
  
• L-Taurine: L-Taurine is a sulfuric amino acid abundant in tissues such as the heart, brain, and skeletal muscle. Taurine is considered a conditionally essential nutrient, meaning that we can produce it in our body, but under demanding conditions we may not produce enough to meet all our needs¹⁶. It improves vasodilation, relaxing the vessels, in addition to reducing blood pressure by decreasing the production of angiotensin II, a potent vasoconstrictor^17,18. Taurine can improve physical performance by increasing the calcium storage capacity of the sarcoplasmic reticulum, as well as the sensitivity of actin and myosin (force-generating proteins) to calcium, thus increasing muscle strength¹⁹. Similarly, it can help performance, increase the use of fat as fuel, in addition to improving mitochondrial function²⁰.
  
  
• L-Tyrosine: L-Tyrosine is a key amino acid in the production of catecholamines, dopamine and norepinephrine, and thyroid hormones, which can be depleted under physical and mental stress conditions. These hormones have a direct implication with the maintenance of cognitive focus, motivation and reduction of the perception of exhaustion. L-Tyrosine has the ability to replenish catecholamine levels in the brain and prevent their decrease, which can be depleted in intense and strenuous workouts^21,22.
  

   

  

   

• Acetyl L-Carnitine (ALC): At the muscular level, L-Carnitine promotes the transport of fatty acids to the mitochondria to produce energy. In addition, it exerts antioxidant benefits, reduces inflammation, and increases nitric oxide levels. Vitobest® it incorporates the acetylated form of L-Carnitine, acetyl-L-Carnitine (ALC), which has a greater ability to cross the blood-brain barrier and reach the brain, also exerting its neurophysiological benefits at the central level^23,24,25.
  

   

  

   

• Dry extract of leaves Ginkgo biloba: The leaves of this tree contain a wide variety of bioactive compounds whose benefits are used to maximize cognitive focus during high-intensity workouts. This is because Ginkgo biloba improves blood flow to the brain and reduces oxidative stress^26,27. It increases the concentrations of dopamine and noradrenaline in the brain, has a direct effect on blood pressure and cortisol peaks secondary to exertion, showing adaptogenic effects. These benefits decrease the perception of exhaustion, maintaining intensity throughout the training^28,29.
  

   

  

   

• Glucosamine sulfate and methylsulfonylmethane (MSM): two active ingredients with anti-inflammatory and protective properties to prevent and treat joint injuries.
  
  > Glucosamine sulfate interferes with the inflammatory cascade involved in collagen degradation, preventing wear and reducing joint pain^30,31.
  
  > Methylsulfonylmethane (MSM) is an organosulfur compound capable of controlling chronic inflammation, in addition to having antioxidant effects at the lipid and protein level, improving joint pain^32,33.
  
  
• Vitamin B3 (niacin): Niacin is a water-soluble vitamin that acts in cellular metabolism as part of the coenzyme NAD and NADP, which are essential in energy metabolism at the cellular level and DNA repair. In addition, it plays a role in muscle endurance by increasing the expression of transcription factors in skeletal muscle that regulate oxidative metabolism and mitochondrial biogenesis^34,35.
  

   

  

   

• Potassium citrate and dicalcium phosphate: Ions are essential for a wide variety of metabolic processes in our bodies. High-intensity or prolonged workouts can lead to their loss, causing temporary deficiencies that directly affect the proper functioning of our muscles and nervous system, negatively impacting our physical and mental state. Therefore, correctly replenishing these ions is key to reducing our sensation of fatigue and maintaining our performance.
  
  
• AstraGin®: This ingredient based on extracts ofPanax notoginsengAndAstragalus membranaceusImproves absorption at the intestinal level, optimizing the effect of the rest of the product's components.
  
  
• DigeZyme™ it is a multienzyme complex that contains amylases, proteases and lipases, three enzymes that are involved in the chemical digestion of carbohydrates, proteins and fats responsible for converting these nutrients into their basic elements (monosaccharides, amino acids and fatty acids) so they can be absorbed at the intestinal level. In addition, this product prevents heavy digestion and its consequences.

Pre Training features:

Pre Training, from Vitobest®, it's the Pre Workout that will bring out all your potential, pushing your workouts to the limit.

Without added carbohydrates or caffeine, Pre Training it adapts to your goals, because you are the one who chooses how far to go. Choose to go all the way, choose Pre Training!

Bibliography:

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²Artioli GG, Gualano B, Smith A, Stout J, Lancha AH Jr. Role of beta-alanine supplementation on muscle carnosine and exercise performance. Med Sci Sports Exerc. (June 2010)

³Stout JR, Cramer JT, Zoeller RF, Torok D, Costa P, Hoffman JR, Harris RC, O'Kroy J. Effects of beta-alanine supplementation on the onset of neuromuscular fatigue and ventilatory threshold in women. Amino Acids. (2007)

⁴Zoeller RF, Stout JR, O'kroy JA, Torok DJ, Mielke M. Effects of 28 days of beta-alanine and creatine monohydrate supplementation on aerobic power, ventilatory and lactate thresholds, and time to exhaustion. Amino Acids. (September 2007)

⁵Kent Sahlin, Roger C HarrisThe creatine kinase reaction: a simple reaction with functional complexityAmino Acids.(May 2011)

⁶Branch JD Effect of creatine supplementation on body composition and performance: a meta-analysis Int J Sport Nutr Exerc Metab. (June 2003)

⁷Wu Y, Hu X, Chen L Effects of Creatine in Trained Athletes: A Meta-analysis of 21 Randomized Placebo-Controlled Trials.Am J Ther.(2020)

⁸Forbes SC, Cordingley DM, Cornish SM, Gualano B, Roschel H, Ostojic SM, Rawson ES, Roy BD, Prokopidis K, Giannos P, Candow DG. Effects of Creatine Supplementation on Brain Function and Health.Nutrients.(2022-Feb-22)

⁹Wu G, Morris SMArginine metabolism: nitric oxide and beyond.Biochem J. (November 15, 1998)

¹⁰Luiking YC, Ten Have GA, Wolfe RR, Deutz NEArginine de novo and nitric oxide production in disease states.Am J Physiol Endocrinol Metab. (Nov-15-2012)

¹¹Eric T Trexler, Adam M Persky, Eric D Ryan, Todd A Schwartz, Lee Stoner, Abbie E Smith-Ryan. Acute Effects of Citrulline Supplementation on High-Intensity Strength and Power Performance: A Systematic Review and Meta-Analysis. Sports Med. (May 2019)

¹²J S Stamler, G MeissnerPhysiology of nitric oxide in skeletal musclePhysiol Rev.(January 2001)

¹³Mutch BJ, Banister EW. Ammonia metabolism in exercise and fatigue: a review. Med Sci Sports Exerc. (1983)

¹⁴Callis A, Magnan de Bornier B, Serrano JJ, Bellet H, Saumade R. Activity of citrulline malate on acid-base balance and blood ammonia and amino acid levels. Study in the animal and in man. Arzneimittelforschung. (June 1991)

¹⁵Besset A, Bonardet A, Rondouin G, Descomps B, Passouant P. Increase in sleep related GH and Prl secretion after chronic arginine aspartate administration in man. Acta Endocrinol (Copenh). (1982 Jan)

¹⁶Lourenço R, Camilo ME Taurine: a conditionally essential amino acid in humans? An overview in health and disease. Nutr Hosp. (2002)

¹⁷da Silva LA, Tromm CB, Bom KF, Mariano I, Pozzi B, da Rosa GL, Tuon T, da Luz G, Vuolo F, Petronilho F, Cassiano W, De Souza CT, Pinho RA. Effects of taurine supplementation following eccentric exercise in young adults. Appl Physiol Nutr Metab. (January 2014)

¹⁸Tawar Qaradakhi, Laura Kate Gadanec, Kristen Renee McSweeney, Jemma Rose Abraham, Vasso Apostolopoulos, Anthony ZulliThe Anti-Inflammatory Effect of Taurine on Cardiovascular DiseaseNutrients.(September 17, 2020)

¹⁹T L Dutka, C R Lamboley, R M Murphy, G D Lamb. Acute effects of taurine on sarcoplasmic reticulum Ca2+ accumulation and contractility in human type I and type II skeletal muscle fibers. J Appl Physiol (1985). (October 1, 2014)

²⁰Jennifer A Kurtz, Trisha A VanDusseldorp, J Andrew Doyle, Jeffrey S Otis. Taurine in Sports and Exercise. J Int Soc Sports Nutr. (May 26, 2021)

²¹Nakashima A, Hayashi N, Kaneko YS, Mori K, Sabban EL, Nagatsu T, Ota A. Role of N-terminus of tyrosine hydroxylase in the biosynthesis of catecholamines. J Neural Transm. (November 2009)

²²Webster D, Wildgoose J. Tyrosine supplementation for phenylketonuria. Cochrane Database Syst Rev. (August 4, 2010)

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²⁸Yoshitake T, Yoshitake S, Kehr J. The Ginkgo biloba extract EGb 761(R) and its main constituent flavonoids and ginkgolides increase extracellular dopamine levels in the rat prefrontal cortex. Br J Pharmacol. (February 1, 2010)

²⁹Jezova D, Duncko R, Lassanova M, Kriska M, Moncek F. Reduction of rise in blood pressure and cortisol release during stress by Ginkgo biloba extract (EGb 761) in healthy volunteers. J Physiol Pharmacol. (2002 Sep)

³⁰Momomura R, Naito K, Igarashi M, Watari T, Terakado A, Oike S, Sakamoto K, Nagaoka I, Kaneko K. Evaluation of the effect of glucosamine administration on biomarkers of cartilage and bone metabolism in bicycle racers. Molecular Medicine Report. (January 25, 2013)

³¹Herrero-Beaumont G, Rovati LC, Castañeda S, Alvarez-Soria MA, Largo R. The reverse glucosamine sulfate pathway: application in knee osteoarthritis. Expert Opin Pharmacother. (Feb 2007)

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³³Nakhostin-Roohi B, Barmaki S, Khoshkhahesh F, Bohlooli S. Effect of chronic supplementation with methylsulfonylmethane on oxidative stress following acute exercise in untrained healthy men. J Pharm Pharmacol. (October 2011)

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³⁵Schuler M1, Ali F, Chambon C, Duteil D, Bornert JM, Tardivel A, Desvergne B, Wahli W, Chambon P, Metzger D. PGC1alpha expression is controlled in skeletal muscles by PPARbeta, whose removal results in fiber-type switching, obesity, and type 2 diabetes. Cell Metab. (2006 Nov)