Liposomal Melatonin

Melatonin: key in sleep and cellular health.

The melatonin It is a hormone produced by the pineal gland, responsible for regulating circadian rhythms and the sleep-wake cycle. With age, its production naturally decreases, which promotes insomnia, chronic fatigue, disruption of the biological clock, and an increase in oxidative stress¹.

In addition to its role in sleep, it actively contributes to the body's nighttime repair processes, supporting physical recovery after exertion and promoting better athletic performance upon waking^10,11.

Liposomal Melatonin, from Vitobest®, offers superior absorption and a gradual release that ensures up to 7 hours of effect, accompanying the entire sleep cycle without causing residual drowsiness.

What are liposomes and how do they enhance the action of melatonin?

Liposomes are microspheres formed by a double layer of phospholipids that encapsulate the melatonin². This technology does not make liposomes directly cross the blood-brain barrier, but rather:

• They protect the melatonin in front of the degradation in the stomach and liver (first pass effect).
• They increase bioavailability, allowing more melatonin active reach the blood³.
• Extend their release, maintaining stable levels for several hours (~7 h)⁴.
• They reduce gastrointestinal irritation, improving tolerance⁵.

In this way, by having more melatonin free in the blood and for a longer time, a greater amount crosses the blood-brain barrier (something it already does naturally), achieving a more effective, stable and long-lasting effect in the brain¹.

Main benefits of liposomal melatonin:

• Restful sleep: reduces the time needed to fall asleep and improves its quality⁶.
• Jet lag relief: reduces the effects of jet lag in travels⁷.
• Antioxidant action: neutralizes free radicals and protects cells⁸.
• Reduction of fatigue and stress: promotes the recovery of the nervous system⁹.
• Recovery and sports performance: promotes nighttime muscle repair and enhances performance upon waking^10,11.
• Clinically proven efficacy: studies show faster onset of action and greater bioavailability with liposomal melatonin³.

The revolution of rest.

Liposomal Melatonin, from Vitobest®, combines the best of sleep science with nutraceutical innovation. Its liposomal technology ensures more efficient absorption, prolonged release, and deep, stable rest.

Maximum absorption. Maximum efficiency. Maximum sleep quality.

Vitobest® used for this supplement vegetable capsules (VegeCaps) suitable for vegan diets and free of titanium dioxide.

Product Claims:

• Melatonin helps to alleviate the subjective feeling of jet lag. The beneficial effect is obtained with a minimum intake of 0.5 mg that should be taken shortly before going to bed on the first day of travel and a few days after arrival at the destination.
• Melatonin helps to reduce the time needed to fall asleep. The beneficial effect is achieved with an intake of 1 mg of melatonin shortly before going to bed.

Bibliography:

¹Hardeland R. Melatonin and the pathologies of weakened or dysregulated circadian oscillators. J Pineal Res. 2017;62(1). [PubMed PMID: 27726221].

²Akbarzadeh A, et al. Liposome: Classification, Preparation, and Applications. Nanoscale Res Lett. 2013;8(1):102. [PubMed PMID: 23391316].

³Scarinci IC, et al. Liposomal delivery systems in nutraceuticals: improved bioavailability of melatonin. Drug Deliv Transl Res. 2022;12(5):1121-1132. (Note: This is a citation from a scientific journal, written in universal citation format. It does not need a translation as it is the same in both English and Spanish.). [PubMed PMID: 34846338].

⁴Paolino D, et al. Ethosomes and elastic liposomes for dermal delivery of melatonin. J Drug Target. 2008;16(3):188-200. [PubMed PMID: 17452098].

⁵Szebeni J, et al. Induction of gastrointestinal tolerance by liposomes. J Liposome Res. 2018;28(2):81-92. [PubMed PMID: 28287063].

⁶Ferracioli-Oda E, Qawasmi A, Bloch MH. Meta-analysis: Melatonin for the treatment of primary sleep disorders. PLoS One. 2013;8(5):e63773. [PubMed PMID: 23741381].

⁷Herxheimer A, Petrie KJ. Melatonin for the prevention and treatment of jet lag. Cochrane Database Syst Rev. 2002;(2):CD001520. [PubMed PMID: 12076414].

⁸Reiter RJ, Tan DX, Rosales-Corral S, Galano A. Melatonin: exceeding expectations. Physiology (Bethesda). 2014;29(5):325-33. [PubMed PMID: 25180261].

⁹This is not a Spanish sentence but a citation of authors. Therefore, the translation in English remains the same: Andersen LP, Gögenur I, Rosenberg J, Reiter RJ. The safety of melatonin in humans. Clin Drug Investig. 2016;36(3):169-175. [PubMed PMID: 26692007].

¹⁰Almendros-Ruiz A, et al. The Effects of Melatonin Supplementation on Professional Football Player Performance: A Systematic Review. (Recovery and performance benefits for professional soccer players).

¹¹Mahdi N, et al. Melatonin Supplementation Enhances Next-Day High-Intensity Exercise Performance and Recovery in Trained Males: A Placebo-Controlled Crossover Study. (Improved performance in high-intensity efforts and reduced physiological fatigue).