NoPain Training | Vitobest® Official
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NoPain

€39.51
€43.90
  • Ideal supplement to consume before training.
  • With Clonapure®, β-Alanine, L-Arginine, L-Citrulline, L-Tyrosine, Oxystorm®, Ashwanature Root® and AstraGin®.
  • Contains 400 mg of natural caffeine (Coffit Nature®).
  • Gluten free, lactose free and no added sugar.
  • Suitable for people with celiac disease.
Size
  • 500 g (1.1 lb)
Flavor
Quantity
En Stock

Vitobest®, in its eagerness to improve the unimprovable, has reformulated its star pre-workout, NoPain.

More muscle congestion, more strength, more endurance, and more focus to push your workouts to the limit.

 

NoPain 01

 

From Vitobest® we know that in order to overcome our limits and push our workouts to the extreme, we must act on all the pathways that influence better sports performance:

  • Strength: Increasing the capacity of our muscles to obtain more energy in less time and enhancing the recruitment of muscle fibers by our nervous system.
  • Resistance: Replenishing the ions that are lost during training and reducing muscle fatigue, maintaining pH balance and reducing the perception of fatigue at the brain level.
  • Anabolism: providing all the available nutrients and oxygen to our muscle fibers to enhance their performance and optimize our own hormonal production.
  • Cognitive focus: stimulating the nervous system to maintain explosiveness and increase intensity for a longer time.

 

NoPain 02

 

NoPain, from Vitobest®, combines the most potent active ingredients along with high doses of caffeine and amino acids that act on these pathways, in addition to being reinforced with minerals to leave nothing to chance:

  • β-Alanine (CarnoSyn®): Non-proteinogenic amino acid precursor of carnosine, whose function is to maintain the acid-base balance in skeletal muscles, the brain, and the heart. Thanks to this buffering, β-Alanine can reduce acidosis without influencing oxygen consumption1,2. β-Alanine also acts at the neuronal level, reducing the perception of fatigue during exercise3. These effects at the muscular and nervous system level promote improvements in performance and athletic explosivity. In addition, numerous studies have confirmed the synergistic effect on athletic performance when combined with creatine4.

  • Clonapure® Creatine: Creatine in its active form, phosphocreatine, is much more effective and provides immediate energy. Creatine mainly acts through its effects on energy metabolism, regenerating cellular ATP5. In this way, it improves strength and power during endurance exercise, as well as increases lean mass6. Numerous studies in athletes confirm their ability to reduce body fat and improve anaerobic exercise performance, strength, and power output7. It also reduces mental fatigue in times of sleep deprivation or exercise to exhaustion8.

     

    Creatine (Clonapure®)

     

  • L-Arginine and L-Citrulline: amino acids directly related to the increase of nitric oxide in blood (NO). NO is a key molecule that promotes vasodilation and, therefore, the arrival of nutrients, oxygen, and hormones to both the muscle and the central nervous system more easily, achieving a reduction in perceived effort, decrease in muscle pain, and increase in power9,10,11. NO could also have direct effects on the contractile function of the muscle12. In addition, they are intermediaries in the urea cycle, responsible for the excretion of ammonia, whose accumulation leads to muscle fatigue during exercise and reabsorption of bicarbonate, reducing acidity13,14. At a hormonal level, L-Arginine can promote anabolism by promoting the secretion of growth hormone15.

  • L-Taurine: L-Taurine is a sulfuric amino acid abundant in tissues such as the heart, brain, and skeletal muscle. Taurine is considered a conditionally essential nutrient, meaning that we can produce it in our body, but under demanding conditions we may not produce enough to meet all our needs16. It improves vasodilation, relaxing the vessels, in addition to reducing blood pressure by decreasing the production of angiotensin II, a potent vasoconstrictor17,18. Taurine can improve physical performance by increasing the calcium storage capacity of the sarcoplasmic reticulum, as well as the sensitivity of actin and myosin (force-generating proteins) to calcium, thus increasing muscle strength19. Similarly, it can help performance, increase the use of fat as fuel, in addition to improving mitochondrial function20.

  • L-Tyrosine: L-Tyrosine is a key amino acid in the production of catecholamines, dopamine and norepinephrine, and thyroid hormones, which can be depleted under physical and mental stress conditions. These hormones have a direct implication with the maintenance of cognitive focus, motivation and reduction of the perception of exhaustion. L-Tyrosine has the ability to replenish catecholamine levels in the brain and prevent their decrease, which can be depleted in intense and strenuous workouts21,22.

     

    NoPain 03

     

  • Dry extract of Rhodiola rosea: The Rhodiola rosea It is an adaptogen that acts at the brain level providing positive effects on sports performance. Studies confirm that it increases strength and power when taken just before training, in addition to reducing the rate of perceived exertion23,24,25. On the other hand, it improves blood flow by acting to inhibit the ACE enzyme at the kidney level, which promotes vasoconstriction26.

  • Sodium citrate, potassium citrate, and calcium bisglycinate: Ions are essential for a wide variety of metabolic processes in our bodies. High-intensity or prolonged workouts can lead to their loss, causing temporary deficiencies that directly affect the proper functioning of our muscles and nervous system, negatively impacting our physical and mental state. Therefore, correctly replenishing these ions is key to reducing our sensation of fatigue and maintaining our performance.

  • Oxystorm®: patented extract of red spinachAmaranthus hypochondriacus) that provides a high concentration of nitrates. Oxystorm® It is capable of increasing the levels of nitrates and nitrites in both saliva and plasma, these being precursors of NO, promoting blood flow and athletic performance27.

     

    NoPain 04

     

  • AshwaNature Root®: Adaptogen with multiple therapeutic uses, where its actions at the level of the nervous, hormonal and metabolic systems provide broad benefits in terms of sports performance28,29,30,31.

    > It reduces the perception of pain and fatigue by stimulating endogenous opioid receptors.
    > Increase theMax VO₂, the strength and muscle size. Moreover, it reduces body fat and increases testosterone levels.
    > Reduces systemic inflammation, oxidative stress and blood lipid levels by regulating insulin levels.

     

    NoPain 05

     

  • Natural Caffeine, Coffit Nature®: Formulated with a dose of 400 mg to produce a more potent effect on the central nervous system, muscle, and adipose tissue. It stimulates the secretion of excitatory neurotransmitters such as dopamine or noradrenaline thanks to its action on two pathways; inhibiting the action of adenosine and the enzyme PDE (cyclic nucleotide phosphodiesterase)32,33,34. It promotes the release of fatty acids to be used as an energy source through mitochondrial oxidation in cells, reducing the percentage of body fat. It increases the intracellular transport of calcium during muscle contraction, directly improving the contraction capacity, the number of muscle fibers recruited, and therefore, muscle strength and hypertrophy35,36,37.

     

    NoPain 06

     

  • AstraGin®: This ingredient based on extracts ofPanax notoginsengAndAstragalus membranaceusImproves absorption at the intestinal level, optimizing the effect of the rest of the product's components.

NoPain features:

 

NoPain 07

 

NoPain, from Vitobest®, it's the definitive Pre Workout, where more strength, more congestion, more energy, and more resistance are combined with inexhaustible power.

 

NoPain 08

 

Bibliography:
1Harris RC, Tallon MJ, Dunnett M, Boobis L, Coakley J, Kim HJ, Fallowfield JL, Hill CA, Sale C, Wise JA. The absorption of orally supplied beta-alanine and its effect on muscle carnosine synthesis in human vastus lateralis. Amino Acids. (May 2006)
2Artioli GG, Gualano B, Smith A, Stout J, Lancha AH Jr. Role of beta-alanine supplementation on muscle carnosine and exercise performance. Med Sci Sports Exerc. (June 2010)
3Stout JR, Cramer JT, Zoeller RF, Torok D, Costa P, Hoffman JR, Harris RC, O'Kroy J. Effects of beta-alanine supplementation on the onset of neuromuscular fatigue and ventilatory threshold in women. Amino Acids. (2007)
4Zoeller RF, Stout JR, O'kroy JA, Torok DJ, Mielke M. Effects of 28 days of beta-alanine and creatine monohydrate supplementation on aerobic power, ventilatory and lactate thresholds, and time to exhaustion. Amino Acids. (September 2007)
5Kent Sahlin, Roger C HarrisThe creatine kinase reaction: a simple reaction with functional complexityAmino Acids.(May 2011)
6Branch JD Effect of creatine supplementation on body composition and performance: a meta-analysis Int J Sport Nutr Exerc Metab. (June 2003)
7Wu Y, Hu X, Chen L Effects of Creatine in Trained Athletes: A Meta-analysis of 21 Randomized Placebo-Controlled Trials.Am J Ther.(2020)
8Forbes SC, Cordingley DM, Cornish SM, Gualano B, Roschel H, Ostojic SM, Rawson ES, Roy BD, Prokopidis K, Giannos P, Candow DG. Effects of Creatine Supplementation on Brain Function and Health.Nutrients.(2022-Feb-22)
9Wu G, Morris SMArginine metabolism: nitric oxide and beyond.Biochem J. (November 15, 1998)
10Luiking YC, Ten Have GA, Wolfe RR, Deutz NEArginine de novo and nitric oxide production in disease states.Am J Physiol Endocrinol Metab. (Nov-15-2012)
11Eric T Trexler, Adam M Persky, Eric D Ryan, Todd A Schwartz, Lee Stoner, Abbie E Smith-Ryan. Acute Effects of Citrulline Supplementation on High-Intensity Strength and Power Performance: A Systematic Review and Meta-Analysis. Sports Med. (May 2019)
12J S Stamler, G MeissnerPhysiology of nitric oxide in skeletal musclePhysiol Rev.(January 2001)
13Mutch BJ, Banister EW. Ammonia metabolism in exercise and fatigue: a review. Med Sci Sports Exerc. (1983)
14Callis A, Magnan de Bornier B, Serrano JJ, Bellet H, Saumade R. Activity of citrulline malate on acid-base balance and blood ammonia and amino acid levels. Study in the animal and in man. Arzneimittelforschung. (June 1991)
15Besset A, Bonardet A, Rondouin G, Descomps B, Passouant P. Increase in sleep related GH and Prl secretion after chronic arginine aspartate administration in man. Acta Endocrinol (Copenh). (1982 Jan)
16Lourenço R, Camilo ME Taurine: a conditionally essential amino acid in humans? An overview in health and disease. Nutr Hosp. (2002)
17da Silva LA, Tromm CB, Bom KF, Mariano I, Pozzi B, da Rosa GL, Tuon T, da Luz G, Vuolo F, Petronilho F, Cassiano W, De Souza CT, Pinho RA. Effects of taurine supplementation following eccentric exercise in young adults. Appl Physiol Nutr Metab. (January 2014)
18Tawar Qaradakhi, Laura Kate Gadanec, Kristen Renee McSweeney, Jemma Rose Abraham, Vasso Apostolopoulos, Anthony ZulliThe Anti-Inflammatory Effect of Taurine on Cardiovascular DiseaseNutrients.(September 17, 2020)
19T L Dutka, C R Lamboley, R M Murphy, G D Lamb. Acute effects of taurine on sarcoplasmic reticulum Ca2+ accumulation and contractility in human type I and type II skeletal muscle fibers. J Appl Physiol (1985). (October 1, 2014)
20Jennifer A Kurtz, Trisha A VanDusseldorp, J Andrew Doyle, Jeffrey S Otis. Taurine in Sports and Exercise. J Int Soc Sports Nutr. (May 26, 2021)
21Nakashima A, Hayashi N, Kaneko YS, Mori K, Sabban EL, Nagatsu T, Ota A. Role of N-terminus of tyrosine hydroxylase in the biosynthesis of catecholamines. J Neural Transm. (November 2009)
22Webster D, Wildgoose J. Tyrosine supplementation for phenylketonuria. Cochrane Database Syst Rev. (August 4, 2010)
23Duncan MJ, Clarke ND. The Effect of Acute Rhodiola rosea Ingestion on Exercise Heart Rate, Substrate Utilisation, Mood State, and Perceptions of Exertion, Arousal, and Pleasure/Displeasure in Active Men. J Sports Med (Hindawi Publ Corp). (2014)
24Yao Lu, Bin Deng, Luhua Xu, Hanjiao Liu, Yinzhi Song, Fengxia Lin. Effects of Rhodiola Rosea Supplementation on Exercise and Sport: A Systematic Review. Front Nutr. (April 7, 2022)
25Noreen EE, Buckley JG, Lewis SL, Brandauer J, Stuempfle KJ. The effects of an acute dose of Rhodiola rosea on endurance exercise performance. J Strength Cond Res. (March 2013)
26Kwon YI, Jang HD, Shetty KEvaluation of Rhodiola crenulata and Rhodiola rosea for management of type II diabetes and hypertensionAsia Pac J Clin Nutr.(2006)
27Subramanian D, Gupta S. Pharmacokinetic study of amaranth extract in healthy humans: A randomized trial. Nutrition. (2016)
28Orrù A, Casu MA, Tambaro S, et al. Withania somnifera (L.) Dunal root extract alleviates formalin-induced pain in mice: involvement of the opioid system. Behavioural Pharmacology 2016; 27: 57–68
29Wankhede S, Langade D, Joshi K, et al. Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial. J Int Soc Sports Nutr 2015; 12: 43
30Pérez-Gómez J, Villafaina S, Adsuar JC, et al. Effects of Ashwagandha (Withania somnifera) on VO2max: A Systematic Review and Meta-Analysis. Nutrients 2020; 12: 1119
31Evaluation-Of-A-Highly-Standardized-WithaniaSomniferaExtract-On-Endothelial-Dysfunction-And-BiomarkersOf-Oxidative-Stress-In-Patients-With-Type-2-DiabetesMellitus.pdf, https://sohonootropics.com/wpcontent/uploads/2020/01/Evaluation-Of-A-Highly-StandardizedWithania-Somniferaextract-On-Endothelial-Dysfunction-AndBiomarkers-Of-Oxidative-Stress-In-Patients-With-Type-2- Diabetes-Mellitus.pdf (accessed December 18, 2020)
32Simone Cappelletti, Daria Piacentino, Gabriele Sani, Mariarosaria AromatarioCaffeine: cognitive and physical performance enhancer or psychoactive drug?Curr Neuropharmacol.(January 2015)
33Kenneth A Jacobson, Zhan-Guo Gao, Pierre Matricon, Matthew T Eddy, Jens Carlsson Adenosine A2A receptor antagonists: from caffeine to selective non-xanthines Br J Pharmacol. (July 2022)
34Fiani B, Zhu L, Musch BL, Briceno S, Andel R, Sadeq N, Ansari AZ. The Neurophysiology of Caffeine as a Central Nervous System Stimulant and the Resultant Effects on Cognition. Function.Cureus.(May 14, 2021)
35Black CD, Waddell DE, Gonglach ARCaffeine's Ergogenic Effects on Cycling: Neuromuscular and Perceptual Factors. Med Sci Sports Exerc. (June 2015)
36Rousseau E, Ladine J, Liu QY, Meissner G. Activation of the Ca2+ release channel of skeletal muscle sarcoplasmic reticulum by caffeine and related compounds. compounds.Arch Biochem Biophys. (November 15, 1988)
37Tarnopolsky M, Cupido C. Caffeine potentiates low frequency skeletal muscle force in habitual and non-habitual caffeine consumers. J Appl Physiol (1985). (November 2000)
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Specific References

ean13
8436594158124

Allergens: does not contain. Gluten-free.

Ingredients: sweetener: erythritol, L-Citrulline DL-Malate, Clonapure® (creatine monohydrate, phosphate, phosphocreatine), β-Alanine (CarnoSyn®), lemon juice powder, acidulant: anhydrous citric acid, L-Arginine (Kyowa®), flavor: bitter blocker, sweetener: xylitol, calcium bisglycinate (Albion™), L-Taurine, L-Tyrosine (Ajinomoto®), dry extract of rhodiola root (Rhodiola rosea), sodium citrate, preservative: potassium citrate, Coffit Nature®: natural caffeine, flavor: lemon, Oxystorm®: dry extract of amaranth leaves (Amaranthus hypochondriacus), AshwaNature Root®: dry extract of ashwagandha root (Withania somnifera), sweeteners: sucralose and acesulfame-K, flavors and AstraGin®: extract of Panax notoginseng and Astragalus membranaceous. Contains caffeine. Not recommended for children or pregnant women (400 mg / 25 g).

Compositionper 25 g
L-Citrulline DL-Malate 4 g
Clonapure®: 3 g
  Creatine monohydrate
  Phosphocreatine
β-Alanine (CarnoSyn®) 3 g
L-Arginine (Kyowa®) 1 g
Calcium bisglycinate (Albion™) 500 mg
  Calcium (Ca) *(11.47 %) 91.8 mg
L-Taurine 500 mg
L-Tyrosine (Ajinomoto®) 500 mg
Dry extract of rhodiola root (Rhodiola rosea)
3 % rosavins and 1 % salidrosides 500 mg
Sodium citrate 400 mg
  Sodium (Na) 108 mg
Potassium citrate 400 mg
  Potassium (K) *(7.57 %) 151.4 mg
Coffit Nature®: natural caffeine 400 mg
Oxystorm®: dry extract of amaranth leaves (Amaranthus hypochondriacus) 250 mg
AshwaNature Root®: dry extract of ashwagandha root (Withania somnifera) 200 mg
AstraGin®: extract of Panax notoginseng and Astragalus membranaceous 25 mg
*% Nutrient Reference Value (NRV)

Nutritional Informationper 25 gper 100 g
Energy value 202 kJ 810 kJ
48 kcal 194 kcal
Fats 0.02 g 0.07 g
  of which are saturated 0.003 g 0.01 g
Carbohydrates 7.9 g 31.6 g
  of which are sugars 0.2 g 0.9 g
Proteins 10.9 g 43.9 g
Salt 0.27 g 1.1 g

Take 25 g (30 cc) mixed in 250 ml of water before exercise.

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